There are over 150 known post transcriptional modifications identified with more being discovered each year. Ranging from a simple methylation to complex hyper-modifications, the chemistry of these molecules is rich and diverse. From purified RNA samples to biofluids, we use high resolution accurate mass tandem mass spectrometry coupled to ultra high performance liquid chromatography (HRAM-UHPLC-MS/MS) to separate, identify and characterize these diverse molecules. Our proprietary strategy ensures that the feature detected in a sample is the target molecule.